endocannabinoid system

The endocannabinoid system (ECS) is a biological systems found in all mammals. It consist of two types of receptors CB1 and CB2, as well as the internally produced endocannabinoids anandamide and 2-AG.


CB2 receptors

These receptors are mostly found in the peripheral organs acting in vital components in the muscular, cardiovascular, and immune systems.

CB1 receptors

These receptors are mostly found in the central nervous system and the brain. But can also be found in other tissues.


Leanna Organics offers a large selection of CBD products to balance your endocannabinoid system.


Before we get into how CBD works, let us start with what it is and some other details. CBD is a compound in a class called Cannabinoids. Cannabinoids interact with what scientists have identified as the “endocannabinoid system” in humans and animals. Cannabinoids appear in nature in only the cannabis plant and endogenously in all mammals. Cannabinoids that come from plants are called phytocannabinoid. The one that our bodies make naturally are called endocannabinoids.

Cannabidiol (CBD) is not intoxicating – in other words, it is not mind-altering.

Cannabidiol, or CBD, is a non-psychoactive compound found in the hemp and marijuana plants. CBD is the most prevalent cannabinoid in the hemp plant, as opposed to THC, which is generally the most prevalent cannabinoid in the Marijuana plant.



The “high” that marijuana is known for, and what is tested for in a drug test is the compound called THC. Many people who are researching how CBD works are concerned about THC. Leanna Organics CBD is grown from Industrial hemp, not marijuana, and we use “zero THC” CBD. However, even “zero THC” CBD has trace amounts of THC present. Therefore those who get drug tested should be cautious of using Leanna Organics CBD or any CBD, as there is no way to remove THC from the hemp plant altogether.



The endocannabinoid system is a balancing system; it up-regulates and downregulates genes in response to what is going on in the body and environment. Our bodies signal and respond via the endocannabinoid system based on many factors; what we eat, how we move, how much and quality of sleep, thoughts and moods, and environmental factors. All of this signaling and responding, up and down regulating, is our bodies attempt to find homeostasis. You may be looking for relief from symptoms, something specific. But how CBD works is different. When taking CBD internally regularly, many users report that they have achieved balance in many parts of their life.



On December 20, 2018, President Trump signed the Hemp Farming Act of 2018. Thus Legalizing CBD nationwide. CBD manufacturers must be able to prove that their CBD is grown from hemp and contains less than .3% THC. All Leanna Organics orders ship with third-party independent testing results. Equally and arguably more important than how CBD works, is that you can consume CBD and use topical CBD without the fear of breaking the law.



Understanding the difference between CBD grown from hemp versus marijuana is vital for those researching how CBD works. Leanna Organics CBD, and any CBD that contains .3% THC or less, is considered industrial hemp. CBD comes from hemp, but some strains of marijuana have CBD. Products that have both THC & CBD appear in dispensaries in states that have a medical marijuana program or recreational program.



Humans have a network of neurons throughout their bodies called the Endocannabinoid system. The receptors in your Endocannabinoid system are called CB1 & CB2 receptors. CB1 receptors are found primarily in the brain and, to a lesser extent, along your spine. THC mainly interacts with CB1 receptors, but CBD does bind as well. CB2 receptors, on the other hand, are found throughout the immune system, traveling in our blood and through most of our organs, inside nerve terminals, and many more places throughout the body. CBD binds mainly to CB2 receptors. There are more cannabinoid receptors in mammals than any other type of receptor. How CBD works depends on application and measurement, Cannabidiol molecules bind to a vast network of receptors throughout the human body. Researchers are still exploring what happens once this bind occurs, but one thing is if for sure, CBD works!



Researchers have nicknamed CBD the “swiss army knife” because of the potential to bind to receptors that are centralized in our immune system and appear throughout our body tissue, muscles, and even the spine. So the answer is that it can help with many mind/body concerns. CBD is classified as a supplement because it replaces compounds that our bodies make internally, like anandamide and 2-AG. How CBD works also depends on which receptor CBD binds. CBD is said to have an affinity to binding with the CB2 receptor, which signals immune response, amongst other essential duties of the body.



Now that we understand the endocannabinoid systems and the receptors that CBD binds. Let us discuss what to expect. CBD is mild. You will not feel intoxicated or even euphoric. You will probably still feel what bothers you, but it will be much more manageable. Often these problems are signals from our bodies. To completely block out this signal is to lose communication with your body. CBD is non-addictive. Many are dissatisfied with harsh addictive pills that present the possibility of moving onto more dangerous and lethal drugs. CBD is non-toxic. There has been only one study that showed toxicity with CBD. But the dose given was much more than any human can or would consume (1/4 of body weight). CBD will serve as a natural alternative to over-the-counter pills that are harmful to the organs in our bodies.



Because CBD is a plant-based, accessible, non-additive, and non-toxic alternative, it is very much about taking wellness back into your own hands. Along with a healthy diet and plenty of movement, CBD can help you achieve balance in your life. Topicals like CBD salve will become the preferred method for addressing discomfort. CBD oil taken every day will naturally bring our bodies and minds into homeostasis. Ready to tackle what is bothering you? Try one of our free CBD salve samples today!



The largest organ on the body is our skin. When using CBD topicals, such as our CBD body cream and CBD face cream, the skin responds. Due to CBD’s powerful ability to fight free radicals and potent ability to lock in moisture, CBD will make your skin glow and never feel softer. Are you ready to see how CBD works for skincare? Check out our free CBD body cream sample!



Internal application – CBD can be taken internally with various degrees of bio-availability. The main difference between internal and external applications is that CBD taken internally reaches your bloodstream. Therefore, internal use is most useful for internal issues. Examples include CBD isolate and CBD oil.

External – Apply CBD externally every day for skincare and wellness. External examples include Body cream, salve, foot cream, lip balm, face cream, eye serum.



How much CBD should I take?

When considering how CBD works, how much should also be evaluated. CBD is safe and non-toxic. There has never been a confirmed overdoes from Cannabis – neither marijuana or hemp. However, there is a matter of bio-availability and a point of diminishing returns. Also, everyone is different, so we broke down our guideline into two categories:

Maintenance: For everyday rejuvenation and care, it is recommended to take CBD internally (tincture, isolate) at a measurement of 5 – 25 MG per serving. Topicals are to be used daily for skincare or as needed for discomfort. CBD does take 1-2 months to build up in your system. So consistency is essential.

Therapeutic: It is always best to consult a physician for serious matters, and it is essential to know that CBD does interact with some medication. The grapefruit warning is a good rule of thumb. If your medication warns against eating grapefruits, you should also abstain from taking CBD (unless recommended by your Dr). CBD at a measurement of 25- 100 MG orally/sublingually per serving.



Everyone is different, and different problems must be addressed differently.

Internally: It is essential to get CBD into your bloodstream. How CBD works when taken internally is much more of a whole-body treatment, as opposed to topicals which only treat a specific area. For CBD for internal use, Leanna Organics offers CBD oil (tincture) and CBD isolate, which is a powder that you can add to food, drinks, or vaporized.

Topically: Leanna Organics offers several topical solutions to apply CBD to the skin: Salve, Body Cream, Lip Balm, Foot Cream, Vapor Rub, Face Cream, and Eye Serum.